Roles of angiopoietin in pathogenesis of wet age-related macular degeneration

doi:10. 3760/cma.j.cn115500-20250223-25409

International Review of Ophthalmology ›› 2025, Vol. 49 ›› Issue (4): 290-297.doi: 10. 3760/cma.j.cn115500-20250223-25409

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Roles of angiopoietin in pathogenesis of wet age-related macular degeneration

Mou Bo^1,2, Xiang Ying², Li Yuanyuan^1,2, Wang Gang^1,2, Song Xiusheng^1,2

1 Hubei Minzu University, Enshi Hubei 445000, China;2 Department of Ophthalmology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Hubei 445000, China

Received:2025-02-23 Online:2025-08-22 Published:2025-08-12
Contact: Song Xiusheng, Email: aeep993@126.com E-mail:aeep993@126.com
Supported by:
Hubei Provincial Natural Science Foundation Joint Fund Project (2024AFD084); Enshi Prefecture Science and Technology Plan Navigating Program (D20230050)

Abstract

Abstract: As another pro-angiogenic factor, angiopoietin plays a key role in the development of Wet age-related macular degeneration (wAMD), and become a hot research topic at present. Studies have demonstrated that angiopoietins influence the pathogenesis and progression of wAMD by modulating vascular stability, endothelial cell proliferation, and neovascularization. Based on this mechanistic understanding, investigating angiopoietin-targeted antagonists has provided novel therapeutic avenues for wAMD treatment.

Key words: Age-related macular degeneration, Angiopoietin

Mou Bo, Xiang Ying, Li Yuanyuan, Wang Gang, Song Xiusheng, . Roles of angiopoietin in pathogenesis of wet age-related macular degeneration[J]. International Review of Ophthalmology, 2025, 49(4): 290-297.

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Roles of angiopoietin in pathogenesis of wet age-related macular degeneration

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